Laboratory of physiology and pathology of the endocrine system

Head of the Laboratory since 2005:
Sholokhov Leonid Fedorovich, Doctor of Medical Sciences, professor

Foundation of the Laboratory dates back to 1988, when the Laboratory of Functional and Experimental Morphology was set up in the Institute of Clinical and Experimental Medicine of the Siberian Branch of the Academy of Medical Sciences USSR, based in Irkutsk (from 1988 to 1990, the Laboratory was headed by Lyubov Ilinichna Kolesnikova). In 1990, the Laboratory was transferred to the Institute of Pediatrics of the East Siberian Office Branch SB AMS USSR, which was organized in Irkutsk on 10 January1990, and was renamed to the Laboratory of Pathophysiology of Pregnancy (from 1990 to 2005, the Laboratory was headed by Kolesnikova, Lyubov Ilinichna). With the expansion of scientific areas in the Laboratory, a group of radioisotope diagnostics was formed, which, on the basis of the Interagency Center for Radioisotope Diagnostics in Irkutsk, participated in hormonal research for the first time not only for scientific purposes, but also for residents of the city and its regions. The Laboratory of Physiology and Pathology of the Endocrine System became an independent subdivision of the Scientific Center in 2005.

The main research areas:

• establishing patterns of changes in the system of neuroendocrine regulation in the formation of adaptive-compensatory processes in various pathological conditions in different ethnic groups, depending on environmental factors;
• development and validation of population reference values of indicators of androgenic function of the ovaries, pituitary-thyroid system and glucocorticoid activity of the adrenal glands in women of reproductive age;
• determining the endocrine function of the gastrointestinal tract and their relationship with the most informative parameters, characterizing the state of intestinal microbiocenosis and vaginal biotope in women of childbearing age with ovarian hyperandrogenism (on the example of polycystic ovary syndrome).

The laboratory cooperates with both Russian and foreign scientific and educational institutions: Irkutsk State University, Irkutsk Branch of S. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk State Medical University, Chita State Medical Academy, The State University of New York (SUNY), Penn State University College of Medicine, USC Keck School of Medicine, Hacettepe University School of Medicine.

The main research results have been published in well-known Russian and international journals: Russian Journal of Physiology, Annals of the Russian Academy of Medical Sciences, Journal Infectology, Infectious Diseases, Therapeutic Archive, Bulletin of Experimental Biology and Medicine, Basic & Clinical Pharmacology & Toxicology, Endocrine Reviews, Journal of Evolutionary Biochemistry and Physiology, Gynecological Endocrinology, Annals of Diabetes Technology & Therapevtics, Sleep Medicine, Medicine (Kaunas, Lithuania), Reproductive sciences, Free Radical Biology and Medicine, Chronobiology International, FEBS journal, etc.

Along with this, based on the research findings, 2 certificates for registering databases and 4 patents were received.

Studies conducted at the Laboratory were used to complete more than 50 doctoral and candidate’s dissertations.