664003, Russian Federation, Irkutsk, Timiryazeva st., 16

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Laboratory of epidemiologically and socially significant infections

Head of the Laboratory since 2011:
Oleg Borisovich Ogarkov, Doctor of Medical Sciences

Огарков.jpg

In 1931, an Epidemiological Department was formed at the Institute of Epidemiology and Microbiology of the Ministry of Health of the Russian SFSR (IEM), where research began in the field of epidemiology and microbiology of respiratory and enteric infections. In 1959, a group of members, involved in intestinal diseases, united and formed the Laboratory of the Epidemiology of Intestinal Infections. The first head of the Laboratory was Kuzina A.I. Subsequently, until 1981, the head of the Laboratory was Cand. Sc. (Med.). Nekipelova G.A. From 1982 to 2011, the Laboratory, renamed to the Laboratory of the Epidemiology of Anthroponosis, was managed by professor, Dr. Sc. (Med.) Savilov E.D. In 1989, the Laboratory as part of the entire IEM became part of the Scientific Centre. Starting from 2011 to the present, the laboratory has been headed by Dr. Sc. (Med.) Ogarkov O.B.

The main research areas:

  • study of molecular epidemiology and microbiology of tuberculosis;
  • clinical trials of HIV/TB disease outcomes, including the study of the pharmacokinetics of TB drugs (in collaboration with the University of Virginia, USA);
  • study of biofilm formation and antibiotic resistance by various pathogenic strains, including MTB; research of mycobacterioses;
  • study of the epidemiology of viral hepatitis and polymorphism of resistance/sensitivity genes to viral hepatitis (together with ISMU), as well as the development of mixed infections (together with ISMU and ISMAPE) for tuberculosis and parenteral viral hepatitis;
  • the epidemiology of anthroponoses and the development of theoretical issues of general epidemiology.

In the 1990s - 2000s, Professor Savilov E.D. and his team suggested theoretical justification and practical application of approaches to the management of the epidemic process in urban areas. As a result of many years of research, it was found that: technogenic environmental pollution is an independent risk factor in the development of infectious and epidemic processes; it was shown that when managing the epidemic process, it was necessary to take into account seasonal and (or) cyclical manifestations of infectious diseases; The influence of technogenic environmental pollution on the effectiveness of vaccine prophylaxis in children was proved; new approaches to assessing water quality by the criterion of biological safety were developed.

In 2000-2005, the concept of the spread of the Beijing genotype of the tuberculosis pathogen in the countries of the former USSR in the 20th century was suggested (Sinkov V.V., Savilov E.D., Ogarkov O.B.)

In 2005-2010, an unfavorable (lethal) combination of the human and pathogen genotypes in tuberculosis was determined (Ogarkov O.B., Sinkov V.V.)

At present time:

  • a model of a polymicrobial biofilm in the focus of necrosis, with multiple/wide drug resistance to tuberculosis is being developed (Ogarkov O.B.);
  • the mobile health approach (eHealth) is being introduced into the practice of treating tuberculosis in HIV-infected patients who are prone to use drugs (Zhdanova S.N.);
  • a search for new biomarkers for tuberculosis is being carried out by introducing methods of genomic DNA sequencing of a new generation (Sinkov V.V.).
  • Since 1994, the Laboratory has been the base for the Department of Epidemiology and Microbiology of the Irkutsk State Medical Academy of Postgraduate Education.

Since 2012, with 2 grants of the Russian Foundation for Basic Research and 2 grants of the U.S. Health Institutes, together with the Medical School of the University of Virginia of the USA, the Laboratory has been researching severe forms of tuberculosis complicated by HIV, drug addiction, etc. Under the established International Collaboration for Infectious Diseases Research (ICIDR), regular meetings are held with the participation of colleagues from the United States, Bangladesh, Tanzania, and Thailand. Ongoing researches have been highly praised by the US Institutes of Health and the Russian Foundation for Basic Research. An example of successful research, aimed at the study of methods for diagnosing and preventing viral infection can be the project of Scott Heysell and Ogarkov O.B. A Personalized Approach to Struggle with the Hiv Epidemic / Drug-Resistant Tuberculosis in Irkutsk.

The main research results of Laboratory staff have been published in well-known international journals: Clinical Infectious Diseases, BMC Genomics, European Respiratory Journal, PLoS One, Public Health Action, Antimicrobial Agents and Chemotherapy, Genomics Data, Molecular Phylogenetics and Evolution, International Journal of Tuberculosis and Lung Disease, mBio.

Members of the Laboratory have defended 11 candidate and 7 doctoral dissertations.